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Experimental evidence showed that activating mitophagy through genetic or pharmacological approaches, especially in the early stages of oxidative stress, can significantly reduce the risk of ferroptosis by clearing and degrading damaged mitochondria, possibly by preventing subsequent metabolic abnormalities from generating excess ROS [115]

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Importantly, Sirtuin localization can vary depending on cell type or cell cycle stage (Pande and Raisuddin 2023)

A meta-analysis (66) incorporating 1,504 patients revealed a significant association between elevated serum copper levels and HF

Mathematically modelling redox cycling is difficult because of the different potential mechanisms through which the process may occur